Lone Star Stroke Research Consortium

The Lone Star Stroke (LSS) Research Consortium is a novel collaboration among leading medical research institutions in Texas to improve the health of Texans affected by stroke and cerebrovascular disease. The mission of LSS is to establish a state-wide network for patient-centered stroke research and therapeutic trials within Texas, linking academic health institutions with proven expertise in stroke research to community stroke centers.

Our objectives are to find better therapies and prevention strategies to improve cerebrovascular health for Texans throughout our state. The 83rd Texas Legislature appropriated $4.5 million for FY14-15 to implement the LSS Research Consortium. University of Texas System administers the LSS funding through an Interagency Agreement with DSHS and contracts to LSS Hubs sites. The LSS Research Consortium has established a robust, georaphically diverse, network of sites that has the capability and infrastructure to implement studies quickly throughout Texas. This is crucial for providing the game-changing breakthroughs that are needed now by people who have or may soon develop a stroke.

UT Health participates as a HUB for the LSS Research Consortium and is currently participating in the following trials that were designed by PI’s at our institution:

Efficient Resources Utilization for Patients with Intracerebral Hemorrhage (EnRICH): PI’s Sean Savitz, MD and Farhaan Vahidy, PhD

Are 90 day outcomes for spontaneous ICH patients with same risk subset associated with level of care? What is the comparative effectiveness for management of spontaneous ICH patients at a higher level of care?  This studies is reviewing healthcare delivery for patients with ICH in community hospitals as well as university affiliated hospitals.  We are comparing the utilization of services, costs of care and outcomes.

Intra-arterial Transfer Time Metric Study (IAT-TiMeS): PI’s Tzu-Ching Wu, MD and Sean Savitz, MD

Intra-arterial therapy for large vessel occlusion has recently been shown to improve outcomes in certain acute stroke patient populations. This had led the AHA/ASA to release guidelines recommending endovascular procedures for selected patients and that systems of care need to be organized to facilitate the delivery of this treatment.  We therefore aim to describe the current landscape of IAT transfer times at Texas CSCs to identify barriers/delays in the transfer process (phase 1). Once we have completed specific aims 1 and 2, we will propose the second phase of this study to address aim 3. We will determine which hospitals have the longest and shortest transfer times and share the data with each of the LSS hospitals. Our objective is for each hospital to learn from each other and evaluate best practices associated with shorter transfer times that could be implemented throughout the network. We will propose specific process improvement initiatives depending on the data analysis from phase 1.  By identifying potential barriers/delays to access to IAT, quality improvement process can be implemented to improve the current system of transfer of patients from PSC to CSC for evaluation of IAT. Faster transfer time may lead to an increase number of patients undergoing IAT translating into better outcomes.

Lone Star Stroke Consortium Telestroke Registry (LeSTER): PI Tzu-Ching Wu, MD

LeSTER is a database that captures preliminary, clinical, treatment, and long term outcomes data on all stroke patients treated via the Telestroke Network of the Lone Star Stroke Consortium. The goal of the database is to  understand the patterns, mechanisms, and impact of regional stroke care in the context of expanding the telestroke network in the state of Texas. We seek to understand how stroke care is delivered and how outcomes are achieved with the use of telemedicine.

You can read more about the Lone Star Stroke Consoritium and the other research projects currently enrolling at http://lonestarstroke.com/