Cerebral Ischemia & Hemorrhage
Main research interest in Dr. Jung’s lab is to identify novel cells-to cells communication, which contributes to stroke recovery via mitochondria-derived small peptides (MDPs) in neurovascular unit. Dr. Jung has been investigating role of mitochondrial peptide transfer among cells in brain, which is involved in neuronal ROS defense, plasticity, and regeneration, as well as microglial switch for cleanup, repair, and functional recovery after stroke. She also has been studying transcriptional changes in oxidative stress-induced genes which are regulated by Signal Transducer and Activator of Transcription (STATs) and other transcription factors. She demonstrated that the mitochondrial-localized antioxidant protein, Mn-SOD is transcriptionally regulated by STAT3 and is a potent neuroprotectant via blocking ROS overproduction in response to brain injury. This discovery laid the groundwork for a better understanding of the role of mitochondria in stroke recovery. Dr. Jung’s research aims to develop the translational approach targeting functional mitochondria in order to prevent neuronal impairment and promote brain remodeling after stroke.