Imaging Core

The primary emphasis of the clinical and translational MR stroke imaging core is to develop qualitative and quantitative surrogate markers of the poststroke prognosis, secondary degeneration, recovery, and treatment efficacy.The neuroimaging scientists at the Magnetic Resonance Image Processing Stroke Core are ready to assist you with your clinical and preclinical imaging needs by designing experiments, optimizing image acquisition protocol, and data analysis. Imaging protocols are designed to evaluate ischemic and hemorrhagic post-stroke lesion volume, white matter integrity, chronic neuronal loss, rate of brain atrophy, cerebral blood perfusion, neuronal circuitry, and metabolic profile.

Typical image acquisition protocol includes: high resolution 3D anatomical images, diffusion tensor imaging, arterial spin labeling, quantitative susceptibility imaging, magnetic resonance spectroscopy, resting state functional MRI.

Quantitative image processing includes: Voxel based morphometry, diffusion tensor matrix, deterministic and propobalistic tractography, cerebral blood volume and cerebral blood flow, lesion segmentation, neuronal network, cortical thickness, iron concentration and metabolite concentration.

We apply matlab based processing code using commercial and freeware software packages such as Analyze, e-film, SPM, FSL, DTI_Studio, STI etc.

The Imaging Core also serves as the imaging analysis center for international stroke trials including the following:

  • A Double-Blind, Controlled Phase 2b Study of the Safety and Efficacy of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke – Sunovion and San Bio, Inc
  • A Double-Blind, Controlled Phase 2 Study of the Safety and Efficacy of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Traumatic Brain Injury (TBI) – San Bio, Inc
  • Sedation versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke – a Randomized Comparative Effectiveness Trial (SEGA)

 

Ponnada A. Narayana, Ph.D., M.Sc.
Professor, Diagnostic and Interventional Imaging
Director

 

 

 

 

 

Muhammad Haque, PhD
Instructor, Department of Neurology

 

 

 

 

 

Clark W. Sitton, M.D.
Associate Professor, Diagnostic and Interventional Imaging